1.1 Principle
1.2 Combinatorial Libraries
2 COMBINATORIAL SYNTHESIS ON SOLID PHASE
2.1 Principle
2.2 Based on the work of Merrifield
2.3 Polymers: the solid support
2.3.1 Cross – Linked Polystyrene
2.3.2 Polyamide Resins
2.3.3 TentaGel Resins
2.4 The linker
2.4.1 Carboxylic acid linkers
2.4.2 Carboxamide linkers
2.4.3 Alcohol linkers
2.4.4 Amine linkers
2.4.5 Traceless linkers
2.4.6 Ultraviolet light sensitive linkers
2.5 Synthesis of a combinatorial library
2.6 Determination of product structure
2.6.1 DNA – based encoding
2.6.2 Peptide tag
2.6.3 Haloaromatic tag or "Hard tag"
2.6.4 Radio-Frequency encoding
2.6.5 Mass encoding
3 COMBINATORIAL SYNTHESIS IN SOLUTION
3.1 Parallel solution synthesis
3.2 Indexed combinatorial libraries
4 APPLICATIONS OF COMBINATORIAL CHEMISTRY
5 COMBINATORIAL CHEMISTRY: A CONCLUSION
5.1 Development of new chemistry on solid phase.
5.2 Integration of combinatorial chemistry with medicinal chemistry